Departments of Psychiatry and Neurobiology, Laboratory of Molecular Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT 06508, USA.
Cell Mol Life Sci. 2013 May;70(10):1739-52. doi: 10.1007/s00018-013-1281-9. Epub 2013 Mar 12.
Recent advances in understanding the cellular and molecular basis of psychiatric illnesses have shed light on the important role played by trophic factors in modulating functional parameters associated with disease causality and drug action. Disease mechanisms are now thought to involve multiple cell types, including neurons and endothelial cells. These functionally distinct but interactively coupled cell types engage in cellular cross talk via shared and common signaling molecules. Dysregulation in their cellular signaling pathways influences brain function and alters behavioral performance. Multifunctional trophic factors such as VEGF and EPO that possess both neurotrophic and angiogenic actions are of particular interest due to their ability to rescue structural and plasticity deficits in neurons and vasculature. Obtaining insight into the behavioral, cellular and molecular actions of multi-functional trophic factors has the potential to open new and transformative therapeutic approaches.
近年来，人们对精神疾病的细胞和分子基础的理解取得了进展，这揭示了营养因子在调节与疾病病因和药物作用相关的功能参数方面的重要作用。目前认为疾病机制涉及多种细胞类型，包括神经元和内皮细胞。这些功能不同但相互作用的细胞类型通过共享和共同的信号分子进行细胞间通讯。它们细胞信号通路的失调会影响大脑功能并改变行为表现。多功能营养因子，如具有神经营养和血管生成作用的 VEGF 和 EPO，由于它们能够挽救神经元和血管系统的结构和可塑性缺陷，因此特别受到关注。深入了解多功能营养因子的行为、细胞和分子作用有可能开辟新的变革性治疗方法。
