Bowa Kasonde, Malyangu E, Wood C, Angelleti P
University Teaching Hospital Lusaka.
Med J Zambia. 2010 Apr;37(2):84-88.
Cancer of the cervix is the most common malignancy in women of childbearing age in Zambia. It is known to be associated with HIV infection and oncogenic strains of HPV. However, there are few studies of penile lesions as a predictor of malignant and premalignant cervical lesions in female partners.
The aim of the study was to determine the association between men with penile lesions and premalignant cervical lesions in their female partners.
Thirty-seven couples were screened for penile and cervical lesions to determine the association between the two. The male partners had a biopsy and the female partners had a Pap smear.
Among 37 female partners, 29 (78.3%) had some type of cervical lesion. Two (5.4%) were undetermined and 6 (16.3%) of the females had normal Pap smears. Among the spouses with diseased cervices 22 (59.4%) were premalignant and 5 (13.5%) were malignant. The combined prevalence of malignant or premalignant cervical lesions among female partners was 73.0%. The HIV prevalence in the cohort was 88.9% (among those who agreed to be tested). The prevalence of premalignant or malignant cervical lesions was 75% in HIV positive and HIV negative females, and 66.7% in those who refused HIV testing.
This small pilot study suggests a high prevalence of premalignant or malignant lesions in females whose partners have penile lesions. In this cohort, HIV infection was not associated with a higher risk of neoplastic cervical lesions.
宫颈癌是赞比亚育龄女性中最常见的恶性肿瘤。已知其与艾滋病毒感染和致癌性人乳头瘤病毒（HPV）毒株有关。然而，关于阴茎病变作为女性伴侣恶性和癌前宫颈病变预测指标的研究较少。
本研究旨在确定患有阴茎病变的男性与其女性伴侣的癌前宫颈病变之间的关联。
对37对夫妇进行阴茎和宫颈病变筛查，以确定两者之间的关联。男性伴侣进行活检，女性伴侣进行巴氏涂片检查。
在37名女性伴侣中，29名（78.3%）患有某种类型的宫颈病变。2名（5.4%）结果未明确，6名（16.3%）女性巴氏涂片检查正常。在宫颈患病的配偶中，22名（59.4%）为癌前病变，5名（13.5%）为恶性病变。女性伴侣中恶性或癌前宫颈病变的综合患病率为73.0%。该队列中的艾滋病毒感染率为88.9%（在同意接受检测的人中）。艾滋病毒阳性和阴性女性中癌前或恶性宫颈病变的患病率为75%，拒绝艾滋病毒检测的女性中这一患病率为66.7%。
这项小型试点研究表明，伴侣患有阴茎病变的女性中，癌前或恶性病变的患病率较高。在该队列中，艾滋病毒感染与宫颈肿瘤性病变的较高风险无关。
