Komissarenko V P, Mestechkina A Y, Mikosha A S
Bull Exp Biol Med. 1975 Jan;77(7):761-3. doi: 10.1007/BF00799312.
The effect of o, p'-dichlorodiphenyldichloroethane (DDD), a compound inducing atrophy of the adrenal cortex and blocking steroid production, on glutathione reductase activity was studied. As a result of feeding dogs with DDD in a dose of 50 mg/kg body weight for 14 days activation of glutathione reducatase took place in the homogenate, cytoplasmic fraction, and disintergrated mitochondria of the adrenals. On the additon of DDD in vitro the activity of the enzyme was unchanged. The content of SH groups expressed per 100 mg tissue was reduced in the homogenate and in all subcellular fractions. If expressed per 100 mg protein in the level of SH groups was lowered only in the microsomes and the disintergrated mitochondria.
研究了一种能诱导肾上腺皮质萎缩并阻断类固醇生成的化合物邻，对'-二氯二苯二氯乙烷（DDD）对谷胱甘肽还原酶活性的影响。给狗喂食剂量为50毫克/千克体重的DDD，持续14天，结果肾上腺匀浆、细胞质部分和破碎的线粒体中的谷胱甘肽还原酶被激活。在体外添加DDD时，该酶的活性未发生变化。每100毫克组织中SH基团的含量在匀浆和所有亚细胞部分均降低。如果以每100毫克蛋白质计算，SH基团的水平仅在微粒体和破碎的线粒体中降低。
