胃电刺激治疗肥胖症的最新进展：系统评价与未来展望
Updates on gastric electrical stimulation to treat obesity: Systematic review and future perspectives.
作者信息
Cha Ryan, Marescaux Jacques, Diana Michele
机构信息
Ryan Cha, Jacques Marescaux, Michele Diana, IHU-Strasbourg, Image-Guided Minimally Invasive Surgical Institute, University of Strasbourg, 67091 Strasbourg, France.
出版信息
World J Gastrointest Endosc. 2014 Sep 16;6(9):419-31. doi: 10.4253/wjge.v6.i9.419.
AIM
To evaluate the current state-of-the-art of gastric electrical stimulation to treat obesity.
METHODS
Systematic reviews of all studies have been conducted to evaluate the effect of different types of gastric electrical stimulation (GES) on obesity.
RESULTS
Thirty-one studies consisting of a total of 33 different trials were included in the systematic review for data analysis. Weight loss was achieved in most studies, especially during the first 12 mo, but only very few studies had a follow-up period longer than 1 year. Among those that had a longer follow-up period, many were from the Transcend(®) (Implantable Gastric Stimulation) device group and maintained significant weight loss. Other significant results included changes in appetite/satiety, gastric emptying rate, blood pressure and neurohormone levels or biochemical markers such as ghrelin or HbA1c respectively.
CONCLUSION
GES holds great promises to be an effective obesity treatment. However, stronger evidence is required through more studies with a standardized way of carrying out trials and reporting outcomes, to determine the long-term effect of GES on obesity.
目的
评估胃电刺激治疗肥胖症的当前技术水平。
方法
对所有研究进行系统评价，以评估不同类型的胃电刺激（GES）对肥胖症的影响。
结果
系统评价纳入了31项研究，共33项不同试验用于数据分析。大多数研究实现了体重减轻，尤其是在最初12个月内，但只有极少数研究的随访期超过1年。在那些随访期较长的研究中，许多来自Transcend（®）（可植入胃刺激）设备组，并维持了显著的体重减轻。其他显著结果分别包括食欲/饱腹感、胃排空率、血压以及神经激素水平或生化标志物（如胃饥饿素或糖化血红蛋白）的变化。
结论
胃电刺激有望成为一种有效的肥胖症治疗方法。然而，需要通过更多采用标准化试验方法和报告结果的研究来提供更有力的证据，以确定胃电刺激对肥胖症的长期影响。
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