为何我不害羞：对托诺尼和奇雷利的回应。
Why I am not shy: a reply to Tononi and Cirelli.
出版信息
Neural Plast. 2013;2013:394946. doi: 10.1155/2013/394946. Epub 2013 Feb 12.
Abstract
In a recent article I reviewed an influential theory of sleep function, the "synaptic homeostasis hypothesis (SHY.)" According to SHY, sleep renormalizes synapses that are potentiated during prior wakefulness. I concluded that while SHY is a seminal theory with important implications about sleep function and the brain, its underlying mechanisms are poorly defined. In an accompanying article, the authors of SHY responded at length. Their reply is thoughtful and provocative, but unfortunately many of the points I raised were not accurately represented or addressed. In this brief commentary, I attempt to clarify some points of confusion. I also explain why any theory of sleep function is incomplete without an understanding of the underlying cellular mechanisms.
摘要
在最近的一篇文章中，我回顾了睡眠功能的一个有影响力的理论，即“突触稳态假说 (SHY)。” 根据 SHY，睡眠使在先前清醒期间被增强的突触恢复正常。我得出的结论是，虽然 SHY 是一个具有重要意义的开创性理论，对睡眠功能和大脑有重要影响，但它的潜在机制还没有被很好地定义。在一篇相关的文章中，SHY 的作者进行了详细的回复。他们的回复深思熟虑且发人深省，但不幸的是，我提出的许多观点都没有被准确地代表或解决。在这篇简短的评论中，我试图澄清一些混淆点。我还解释了为什么如果不了解潜在的细胞机制，任何睡眠功能理论都是不完整的。
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