慢波活动增强以改善认知。
Slow-Wave Activity Enhancement to Improve Cognition.
机构信息
University of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh, PA, USA.
University of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh, PA, USA.
出版信息
Trends Neurosci. 2018 Jul;41(7):470-482. doi: 10.1016/j.tins.2018.03.003. Epub 2018 Apr 5.
Abstract
Slow-wave activity (SWA), and its coupling with other sleep features, reorganizes cortical circuitry, supporting cognition. This raises the question: can cognition be improved through SWA enhancement? SWA enhancement techniques range from behavioral interventions (such as exercise), which have high feasibility but low specificity, to laboratory-based techniques (such as transcranial stimulation), which have high specificity but are less feasible for widespread use. In this review we describe the pathways through which SWA is enhanced. Pathways encompass enhanced neural activity, increased energy metabolism, and endocrine signaling during wakefulness; also direct enhancement during sleep. We evaluate the robustness and practicality of SWA-enhancement techniques, discuss approaches for determining a causal role of SWA on cognition, and present questions to clarify the mechanisms of SWA-dependent cognitive improvements.
摘要
慢波活动（SWA）及其与其他睡眠特征的耦合会重新组织皮质电路，从而支持认知。这就提出了一个问题：是否可以通过增强 SWA 来提高认知能力？SWA 增强技术的范围从行为干预（如运动），具有高可行性但特异性低，到基于实验室的技术（如经颅刺激），具有高特异性但不太可行广泛使用。在这篇综述中，我们描述了增强 SWA 的途径。途径包括在清醒时增强神经活动、增加能量代谢和内分泌信号；以及在睡眠期间直接增强。我们评估了 SWA 增强技术的稳健性和实用性，讨论了确定 SWA 对认知的因果作用的方法，并提出了一些问题来阐明 SWA 依赖认知改善的机制。
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