Department of Biomedical Sciences, Elson S. Floyd College of Medicine, Washington State University Spokane, Pharmaceutical and Biomedical Science Building 213, 412 E. Spokane Falls Blvd., Spokane, WA 99202, USA.
Biology (Basel). 2016 Jul 13;5(3):31. doi: 10.3390/biology5030031.
Circadian rhythms refer to oscillations in biological processes with a period of approximately 24 h. In addition to the sleep/wake cycle, there are circadian rhythms in metabolism, body temperature, hormone output, organ function and gene expression. There is also evidence of circadian rhythms in synaptic plasticity, in some cases driven by a master central clock and in other cases by peripheral clocks. In this article, I review the evidence for circadian influences on synaptic plasticity. I also discuss ways to disentangle the effects of brain state and rhythms on synaptic plasticity.
昼夜节律是指大约 24 小时周期的生物过程波动。除了睡眠/觉醒周期外，代谢、体温、激素分泌、器官功能和基因表达也存在昼夜节律。突触可塑性也存在昼夜节律，在某些情况下受中央主钟驱动，在其他情况下受外周钟驱动。本文综述了昼夜节律对突触可塑性的影响的证据。还讨论了如何区分大脑状态和节律对突触可塑性的影响。
