Rupprecht C E, Gilbert J, Pitts R, Marshall K R, Koprowski H
Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104.
J Am Vet Med Assoc. 1990 May 15;196(10):1614-6.
Efficacy of an SC-administered commercial inactivated vaccine for prevention of rabies was evaluated in domestic ferrets. Ferret immunity was challenged by the IM inoculation of street rabies virus. All ferrets developed titers of rabies virus-neutralizing antibodies within 30 days of vaccination (geometric mean titer [GMT] = 154, n = 41) that were maintained for at least one year (GMT = 106, n = 36), compared with no seroconversion in controls (GMT less than 5, n = 39). Following rabies virus challenge inoculation, 89% (32/36) of vaccinated ferrets survived vs less than 6% (2/38) survival in control ferrets. These results demonstrate the protective efficacy of a commercial, inactivated rabies vaccine of at least one year's duration for domestic ferrets.
在驯养雪貂中评估了皮下注射一种市售灭活狂犬病疫苗预防狂犬病的效果。通过肌肉注射街毒株狂犬病病毒来激发雪貂的免疫反应。所有接种疫苗的雪貂在接种后30天内都产生了狂犬病病毒中和抗体效价（几何平均滴度[GMT]=154，n=41），并且至少维持了一年（GMT=106，n=36），而对照组没有发生血清转化（GMT<5，n=39）。在接种狂犬病病毒激发疫苗后，89%（32/36）的接种疫苗的雪貂存活，而对照雪貂的存活率不到6%（2/38）。这些结果证明了一种市售灭活狂犬病疫苗对驯养雪貂具有至少一年的保护效力。
