Hoover J P, Baldwin C A, Rupprecht C E
Department of Medicine and Surgery, College of Veterinary Medicine, Oklahoma State University, Stillwater 74278.
J Am Vet Med Assoc. 1989 Jan 15;194(2):234-8.
Nine unrelated 12-week-old naive domestic ferrets (Mustela putorius furo) were used to evaluate the serologic responses to commercial canine distemper virus (CDV) and rabies virus (RV) vaccines. Five of the ferrets (group 1) were inoculated 3 times at 2-week intervals with a multivalent modified-live virus vaccine of canine cell-line origin, containing CDV and an inactivated RV vaccine. Four of the ferrets (group 2) were inoculated once with the multivalent modified-live virus vaccine containing CDV and were not inoculated with the RV vaccine. Both group-1 and group-2 ferrets seroconverted to the CDV component of the vaccine. Group-1 ferrets also seroconverted after RV vaccination and maintained serum antibody titers to both CDV and RV for at least 7 months. Domestic ferret sera were found to have IgG epitopes similar to sera of domestic dogs and cats. Domestic ferret sera did not contain antibodies to feline coronavirus or FeLV antigens.
选用9只12周龄、无亲缘关系的未接触过病原体的家养雪貂（鼬属欧洲雪貂）来评估其对市售犬瘟热病毒（CDV）和狂犬病病毒（RV）疫苗的血清学反应。其中5只雪貂（第1组）每隔2周接种3次犬细胞系来源的多价减毒活疫苗，该疫苗含CDV以及一种灭活RV疫苗。另外4只雪貂（第2组）接种1次含CDV的多价减毒活疫苗，未接种RV疫苗。第1组和第2组雪貂均对疫苗中的CDV成分发生血清转化。第1组雪貂在接种RV疫苗后也发生了血清转化，并且对CDV和RV的血清抗体滴度至少维持了7个月。发现家养雪貂血清具有与家犬和家猫血清相似的IgG表位。家养雪貂血清不含抗猫冠状病毒或猫白血病病毒抗原的抗体。
