通过银（I）催化乙烯基重氮酯和腈的环加成反应合成新的吡咯。
A new pyrrole synthesis via silver(I)-catalyzed cycloaddition of vinylogous diazoester and nitrile.
机构信息
Hoffmann-La Roche Inc., pRED, Pharma Research & Early Development, Small Molecule Research, Discovery Chemistry, 340 Kingsland Street, Nutley, New Jersey 07110, United States.
出版信息
Org Lett. 2013 Apr 5;15(7):1421-3. doi: 10.1021/ol400062w. Epub 2013 Mar 11.
PMID:23477583
Abstract
A new synthesis of di- and trisubstituted pyrroles was achieved by treating in situ generated vinylogous diazoesters and readily available nitriles with a catalytic amount of silver(I) antimony hexafluoride at room temperature. This method showcased the potential of utilizing silver(I) carbenoids in preparing heterocyclic compounds.
摘要
一种新的二取代和三取代吡咯的合成方法是通过在室温下用催化量的六氟锑酸银（I）处理原位生成的乙烯基重氮酯和易得的腈来实现的。该方法展示了利用银（I）碳烯在制备杂环化合物方面的潜力。
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