Benichou M, Lorino A M, Lorino H, Macquin-Mavier I, Istin N, Harf A
Département de Physiologie, Institut National de la Santé et de la Recherche Médicale U296, Hôpital Henri Mondor, Creteil, France.
J Appl Physiol (1985). 1990 Apr;68(4):1634-9. doi: 10.1152/jappl.1990.68.4.1634.
The effects of tidal volume amplitude on bronchopulmonary reactivity were investigated in three groups of 14 anesthetized paralyzed mechanically ventilated guinea pigs. Animals of group 1 served as control; in animals of group 2, both the sympathetic and parasympathetic nervous systems were blocked; in animals of group 3, only the parasympathetic system was blocked. In each group, the animals were randomly divided into two subgroups characterized by their ventilatory pattern: rate of 60/min with a 6-ml/kg tidal volume or rate of 40/min with a 9-ml/kg tidal volume. Bronchopulmonary reactivity to infused histamine was assessed by the respiratory compliance and conductance values measured during bronchoconstriction and expressed as a percentage of the corresponding basal values. In group 1 the animals ventilated with a 9-ml/kg tidal volume were found significantly less reactive than those ventilated with a 6-ml/kg tidal volume. This difference was abolished in groups 2 and 3. These results demonstrate that the effects of increased tidal volume on bronchopulmonary reactivity are vagally mediated and suggest that the decrease observed in histamine-induced bronchoconstriction is mainly due to reflex effects evoked by stretch receptor stimulation.
在三组共42只麻醉、瘫痪并接受机械通气的豚鼠中，研究了潮气量幅度对支气管肺反应性的影响。第1组动物作为对照；第2组动物的交感神经系统和副交感神经系统均被阻断；第3组动物仅副交感神经系统被阻断。在每组中，动物被随机分为两个亚组，其通气模式不同：潮气量为6 ml/kg、呼吸频率为60次/分钟，或潮气量为9 ml/kg、呼吸频率为40次/分钟。通过在支气管收缩期间测量的呼吸顺应性和传导率值评估支气管肺对注入组胺的反应性，并表示为相应基础值的百分比。在第1组中，发现潮气量为9 ml/kg通气的动物比潮气量为6 ml/kg通气的动物反应性明显更低。在第2组和第3组中，这种差异消失了。这些结果表明，潮气量增加对支气管肺反应性的影响是由迷走神经介导的，并表明组胺诱导的支气管收缩中观察到的降低主要是由于牵张感受器刺激引起的反射效应。
