Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
Cell Res. 2013 Jun;23(6):735-6. doi: 10.1038/cr.2013.32. Epub 2013 Mar 12.
Paramyxoviruses evade antiviral immune response using a small nonstructural protein, V, which binds to the host dsRNA sensor MDA5 and prevents it from activating the interferon signaling pathway. A recent crystal structure of the V protein in complex with MDA5, published in Science, revealed that V disrupts the structure of MDA5 and is integrated into the MDA5 protein fold, providing an intriguing new example of viral mimicry as a countermeasure against the host immune system.
副黏病毒利用一种小的非结构蛋白 V 来逃避抗病毒免疫反应，V 蛋白与宿主 dsRNA 传感器 MDA5 结合，阻止其激活干扰素信号通路。最近在《科学》杂志上发表的 V 蛋白与 MDA5 复合物的晶体结构揭示，V 蛋白破坏 MDA5 的结构并整合到 MDA5 蛋白折叠中，为病毒模拟作为对抗宿主免疫系统的对策提供了一个有趣的新例子。
