Department of Biomechanics, Medicine and Rehabilitation, Faculty of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil.
Am J Phys Med Rehabil. 2013 May;92(5):402-10. doi: 10.1097/PHM.0b013e318287697c.
The aim of this study was to compare the effect of standing frame and electrical stimulation on bone quality in a rodent transection model of spinal cord injury (SCI).
Seven-week-old male Wistar rats were divided into four groups: sham, n = 10; SCI, n = 7; SCI + standing frame, n = 7; and SCI + electrical stimulation, n = 7. Complete SCI was generated by surgical transection of the cord at the T10 level. Therapies were initiated 3 days after the surgery, 3 days/wk, 20 mins/day, for 30 days. Animals were killed on day 33 postinjury.
No treatment preserved bone mineral density at any skeletal site tested (P = 0.08-0.99). Standing frame therapy preserved maximal load at the lumbar vertebral body (14% vs. 37% reduction, P = 0.01) and prevented SCI-induced loss of stiffness at both the femur (8% vs. 37% reduction, P = 0.03) and the tibia (35% vs. 56% reduction, P < 0.0001). Electrical stimulation therapy reduced SCI-induced loss of stiffness at the tibia only (40% vs. 56% reduction, P = 0.003).
Standing frame and electrical stimulation may have potential as future therapeutic modalities to treat or prevent bone loss after SCI.
本研究旨在比较站立架和电刺激对脊髓损伤（SCI）大鼠横切模型骨质量的影响。
7 周龄雄性 Wistar 大鼠分为 4 组：假手术组，n = 10；SCI 组，n = 7；SCI + 站立架组，n = 7；SCI + 电刺激组，n = 7。通过 T10 水平脊髓横切手术产生完全性 SCI。术后 3 天开始治疗，每周 3 天，每天 20 分钟，共 30 天。动物在损伤后第 33 天处死。
没有任何治疗方法能在任何测试的骨骼部位保留骨密度（P = 0.08-0.99）。站立架治疗能保留腰椎体的最大负荷（14% vs. 37%的减少，P = 0.01），并防止 SCI 引起的股骨（8% vs. 37%的减少，P = 0.03）和胫骨（35% vs. 56%的减少，P < 0.0001）刚度丧失。电刺激治疗仅能减少 SCI 引起的胫骨刚度丧失（40% vs. 56%的减少，P = 0.003）。
站立架和电刺激可能具有作为未来治疗 SCI 后骨丢失的治疗或预防方法的潜力。
