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基于电刺激的骨折治疗效果如果这么好,为什么没有更多的外科医生使用它?

Electrical stimulation-based bone fracture treatment, if it works so well why do not more surgeons use it?

机构信息

Frankfurt Initiative for Regenerative Medicine, Experimental Trauma and Orthopedic Surgery, J.W. Goethe-University, Friedrichsheim gGmbH, Haus 97 B, 1OG, Marienburgstraße. 2, 60528, Frankfurt am Main, Germany.

Department of Orthopedics and Rehabilitation, University of New Mexico, Albuquerque, NM, USA.

出版信息

Eur J Trauma Emerg Surg. 2020 Apr;46(2):245-264. doi: 10.1007/s00068-019-01127-z. Epub 2019 Apr 6.

Abstract

BACKGROUND

Electrical stimulation (EStim) has been proven to promote bone healing in experimental settings and has been used clinically for many years and yet it has not become a mainstream clinical treatment.

METHODS

To better understand this discrepancy we reviewed 72 animal and 69 clinical studies published between 1978 and 2017, and separately asked 161 orthopedic surgeons worldwide about their awareness, experience, and acceptance of EStim for treating fracture patients.

RESULTS

Of the 72 animal studies, 77% reported positive outcomes, and the most common model, bone, fracture type, and method of administering EStim were dog, tibia, large bone defects, and DC, respectively. Of the 69 clinical studies, 73% reported positive outcomes, and the most common bone treated, fracture type, and method of administration were tibia, delayed/non-unions, and PEMF, respectively. Of the 161 survey respondents, most (73%) were aware of the positive outcomes reported in the literature, yet only 32% used EStim in their patients. The most common fracture they treated was delayed/non-unions, and the greatest problems with EStim were high costs and inconsistent results.

CONCLUSION

Despite their awareness of EStim's pro-fracture healing effects few orthopedic surgeons use it in their patients. Our review of the literature and survey indicate that this is due to confusion in the literature due to the great variation in methods reported, and the inconsistent results associated with this treatment approach. In spite of this surgeons seem to be open to using this treatment if advancements in the technology were able to provide an easy to use, cost-effective method to deliver EStim in their fracture patients.

摘要

背景

电刺激(EStim)已被证明可促进实验环境中的骨愈合,并已在临床上使用多年,但尚未成为主流的临床治疗方法。

方法

为了更好地理解这种差异,我们回顾了 1978 年至 2017 年间发表的 72 项动物研究和 69 项临床研究,并分别向全球 161 名骨科医生询问他们对 EStim 治疗骨折患者的意识、经验和接受程度。

结果

在 72 项动物研究中,77%的研究报告了积极的结果,最常见的模型、骨骼、骨折类型和 EStim 给药方式分别为狗、胫骨、大骨缺损和直流电。在 69 项临床研究中,73%的研究报告了积极的结果,最常见的治疗骨骼、骨折类型和给药方式分别为胫骨、延迟/不愈合和 PEMF。在 161 名调查受访者中,大多数(73%)了解文献中报告的积极结果,但只有 32%的受访者在其患者中使用 EStim。他们治疗的最常见骨折是延迟/不愈合,EStim 最大的问题是成本高和结果不一致。

结论

尽管骨科医生了解 EStim 对骨折愈合的有益作用,但很少将其用于患者。我们对文献的回顾和调查表明,这是由于文献中报道的方法差异很大,以及与这种治疗方法相关的结果不一致,导致混淆。尽管如此,如果这项技术能够提供一种易于使用且具有成本效益的方法来为骨折患者提供 EStim,外科医生似乎愿意使用这种治疗方法。

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