Parasitology Department, Rouen University Hospital & EA 3800, University of Rouen, Rouen, France.
Antimicrob Agents Chemother. 2013 Jun;57(6):2821-3. doi: 10.1128/AAC.01538-12. Epub 2013 Mar 11.
Nitazoxanide and three halogeno-thiazolides, RM-4850, RM-4865, and RM-5038, were tested against Cryptosporidium parvum in experimentally infected immunosuppressed Mongolian gerbils. Daily 400-mg/kg doses of the four test drugs for 5 to 8 consecutive days produced similar reductions of oocyst shedding. Using early-infected gerbils, a shorter 4-day treatment with RM-5038 reduced oocyst shedding by 95%, compared to 47% for nitazoxanide (P = 0.02), suggesting that RM-5038 is more effective than nitazoxanide under the experimental conditions used.
硝唑尼特和三种卤代噻唑啉类化合物 RM-4850、RM-4865 和 RM-5038 对实验感染免疫抑制的蒙古沙鼠体内的微小隐孢子虫进行了测试。每日 400mg/kg 剂量的四种受试药物连续使用 5 至 8 天，可使卵囊脱落量相似减少。使用早期感染的沙鼠，用 RM-5038 进行更短的 4 天治疗，可使卵囊脱落减少 95%，而硝唑尼特为 47%（P=0.02），表明在使用的实验条件下，RM-5038 比硝唑尼特更有效。
