D'Amico Arnaldo, Di Natale Corrado, Falconi Christian, Martinelli Eugenio, Paolesse Roberto, Pennazza Giorgio, Santonico Marco, Sterk Peter Jason
University of Rome Tor Vergata, Department of Electronic Engineering , Via del Politecnico, 1 - 00133 Rome , Italy +39 06 7259 7349 ; +39 06 2020 519 ;
Expert Opin Med Diagn. 2012 May;6(3):175-85. doi: 10.1517/17530059.2012.665870.
The early determination of serious pathologies has so far been an important issue in both the medical and social fields. The search for an instrument able to detect cancers has led to the consideration of the usage of chemicals of the human body, which carry, through its volatile compounds, information coming from or related to defined pathologies.
The electronic nose (EN) seems to represent a good solution for the detection of cancers of different types. Recent results showed the utility of an EN to smell chemicals related to lung, melanoma, prostatic, breast and pancreatic cancers. The results obtainable from ENs are chemical images and, as it will be shown in this paper, the probability of cancer recognition is rather high. Main results obtained at international level and by the authors of this paper will be commented upon.
A personal opinion is given trying to foresee future developments of the olfaction strategy. To this purpose, two main aspects are considered: looking for better overall stability of the EN and for a new use of ENs in detecting alterations between blood and pathology components.
迄今为止,早期确定严重病症在医学和社会领域都是一个重要问题。寻找能够检测癌症的仪器促使人们考虑使用人体化学物质,这些化学物质通过其挥发性化合物携带来自特定病症或与特定病症相关的信息。
电子鼻似乎是检测不同类型癌症的一个很好的解决方案。最近的结果表明,电子鼻可用于嗅闻与肺癌、黑色素瘤、前列腺癌、乳腺癌和胰腺癌相关的化学物质。从电子鼻中获得的结果是化学图像,正如本文将展示的那样,癌症识别的概率相当高。将对国际层面以及本文作者所取得的主要成果进行评论。
给出了个人观点,试图预见嗅觉策略的未来发展。为此,考虑了两个主要方面:寻求电子鼻更好的整体稳定性以及电子鼻在检测血液与病理成分之间变化方面的新用途。