Songsivilai S, Dharakul T, Kanistanon D
Department of Immunology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Trans R Soc Trop Med Hyg. 1996 Sep-Oct;90(5):505-7. doi: 10.1016/s0035-9203(96)90296-5.
The prevalences of infections with hepatitis C virus (HCV) and hepatitis B virus (HBV) were determined in 110 Thai patients with liver cancer, of whom 80 and 30 had histological diagnoses of hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), respectively. Hepatitis B surface antigen was detected in 63.8% of HCC patients and 16.7% of those with CCA. Antibodies to HCV, detected by a third-generation enzyme immunoassay, were found in 11.3% of HCC patients and in no CCA patient. HCV ribonucleic acid (RNA) was detected by polymerase chain reaction in 6 anti-HCV positive patients, and also in 2 patients who had no detectable anti-HCV antibody. A total of 11 patients had evidence of HCV infection, 8 of whom were infected with HCV alone. HCV genotypes were determined in all 8 patients who had HCV RNA; genotype 3a was the most common (62.5%). These results demonstrate that, in Thailand where both HBV and HCV are endemic, HBV infection is still the most important risk factor for HCC, but HCV also has an important role in those without HBV infection. In addition, the genotypic distribution of HCV in HCC in Thailand is similar to that in the general population. No specific association between genotype 1b and HCC was observed.
在110例泰国肝癌患者中测定了丙型肝炎病毒（HCV）和乙型肝炎病毒（HBV）的感染率，其中80例和30例分别经组织学诊断为肝细胞癌（HCC）和胆管癌（CCA）。在63.8%的HCC患者和16.7%的CCA患者中检测到乙型肝炎表面抗原。通过第三代酶免疫测定法检测到，11.3%的HCC患者存在抗HCV抗体，而CCA患者中未检测到。通过聚合酶链反应在6例抗HCV阳性患者以及2例未检测到抗HCV抗体的患者中检测到HCV核糖核酸（RNA）。共有11例患者有HCV感染证据，其中8例仅感染HCV。在所有8例有HCV RNA的患者中测定了HCV基因型；3a基因型最为常见（62.5%）。这些结果表明，在HBV和HCV均为地方流行的泰国，HBV感染仍是HCC最重要的危险因素，但HCV在无HBV感染的患者中也起着重要作用。此外，泰国HCC中HCV的基因型分布与普通人群相似。未观察到1b基因型与HCC之间存在特定关联。
