Department of Cell Biochemistry, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Kraków, Poland.
Cytokine. 2013 Apr;62(1):22-33. doi: 10.1016/j.cyto.2013.02.007. Epub 2013 Mar 6.
This review focuses on the mechanisms by which the expression of specific genes is regulated by two proteins that are important in inflammation and cancer, namely the pro-inflammatory cytokine interleukin (IL)-1β and epidermal growth factor (EGF). In the review the receptors that recognize factors that cause inflammation are described with main focus on the receptors associated with activation of IL-1β. The function of IL-1β and pathways leading to activation of transcription factors, particularly NFκB and Elk-1 are analyzed. Then the mechanisms of EGF action, with particular emphasis of the activation of Elk-1 are illustrated. The link between aberrant signaling of EGF receptor family members and cancer development is explained. The relationship between inflammation and tumorigenesis is discussed.
这篇综述重点介绍了两种在炎症和癌症中起重要作用的蛋白质（促炎细胞因子白细胞介素 (IL)-1β和表皮生长因子 (EGF)）调节特定基因表达的机制。在综述中，描述了识别引起炎症的因子的受体，主要关注与 IL-1β 激活相关的受体。分析了 IL-1β 的功能和导致转录因子激活的途径，特别是 NFκB 和 Elk-1。然后说明了 EGF 作用的机制，特别强调了 Elk-1 的激活。解释了 EGF 受体家族成员异常信号与癌症发展之间的联系。讨论了炎症与肿瘤发生之间的关系。
