Luanpitpong Sudjit, Iyer Anand Krishnan V, Azad Neelam, Wang Liying, Rojanasakul Yon
Department of Pharmaceutical Sciences, Hampton University, Hampton, Virginia.
For Immunopathol Dis Therap. 2012 Jan 1;3(2):141-154. doi: 10.1615/ForumImmunDisTher.2012006115.
Nitric oxide (NO) has been widely recognized as an important cell-signaling molecule that regulates various physiological and pathological processes. -nitrosylation, or covalent attachment of NO to protein sulfhydryl groups, is a key mechanism by which NO regulates protein functions and cellular processes. In this article we discuss the various roles of NO and protein nitrosylation in cancer development, with a focus on cell invasion and anoikis resistance, both of which are key determinants of cancer metastasis. We specially address some of the mechanisms by which NO-mediated -nitrosylation modulates substrates that have putative effects on key steps of metastasis. We propose that nitrosothiol signaling is a key regulatory mechanism common to several pathways involved in cancer progression and metastasis, and identifying such a mechanism will improve our understanding of the disease process and aid in the development of novel anticancer therapeutics.
一氧化氮（NO）已被广泛认为是一种重要的细胞信号分子，可调节各种生理和病理过程。蛋白质的亚硝基化，即NO与蛋白质巯基的共价连接，是NO调节蛋白质功能和细胞过程的关键机制。在本文中，我们讨论了NO和蛋白质亚硝基化在癌症发展中的各种作用，重点关注细胞侵袭和失巢凋亡抗性，这两者都是癌症转移的关键决定因素。我们特别阐述了NO介导的亚硝基化调节对转移关键步骤有假定影响的底物的一些机制。我们提出亚硝基硫醇信号传导是癌症进展和转移所涉及的几种途径共有的关键调节机制，识别这种机制将增进我们对疾病过程的理解，并有助于开发新型抗癌疗法。
