对氧磷酶 1 和 2 基因多态性与波兰人群多发性硬化症的风险。
Polymorphisms of paraoxonase 1 and 2 genes and the risk of multiple sclerosis in the Polish population.
机构信息
Katedra i Klinika Neurologii, Warszawski Uniwersytet Medyczny, Warszawa, Polska.
出版信息
Neurol Neurochir Pol. 2013 Jan-Feb;47(1):49-52. doi: 10.5114/ninp.2013.32935.
BACKGROUND AND PURPOSE
The aim of this study was to test the hypothesis that polymorphisms of the paraoxonase genes PON1 and PON2 may be associated with increased risk of developing multiple sclerosis (MS) in the Polish population.
MATERIAL AND METHODS
We studied the significance of the PON gene polymorphisms C311S, A162G, Q192R and L55M in 221 patients (including 145 women) with MS and in 661 healthy controls. In the MS population, mean Expanded Disability Status Scale score was 2.92, mean age was 36.8 years, and mean disease duration was 7.7 years. PON genotyping was determined using polymerase chain reaction and restriction enzyme digestion.
RESULTS
According to our results, the PON1 and PON2 genotypes distribution did not differ between the MS patients and the controls.
CONCLUSIONS
The polymorphisms of the PON genes studied are not related to increased risk of MS in the Polish population.
背景与目的
本研究旨在检验假设，即对氧磷酶基因 PON1 和 PON2 的多态性可能与波兰人群多发性硬化症（MS）发病风险增加有关。
材料与方法
我们研究了 221 名 MS 患者（包括 145 名女性）和 661 名健康对照者的 PON 基因多态性 C311S、A162G、Q192R 和 L55M 的意义。MS 人群的扩展残疾状况量表评分平均值为 2.92，平均年龄为 36.8 岁，平均病程为 7.7 年。PON 基因分型采用聚合酶链反应和限制性内切酶消化法确定。
结果
根据我们的结果，MS 患者和对照组之间 PON1 和 PON2 基因型分布无差异。
结论
研究中 PON 基因的多态性与波兰人群 MS 发病风险增加无关。
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