高密度脂蛋白和血管内皮保护。
HDL and endothelial protection.
机构信息
INSERM UMR698, Paris, France.
出版信息
Br J Pharmacol. 2013 Jun;169(3):493-511. doi: 10.1111/bph.12174.
Abstract
High-density lipoproteins (HDLs) represent a family of particles characterized by the presence of apolipoprotein A-I (apoA-I) and by their ability to transport cholesterol from peripheral tissues back to the liver. In addition to this function, HDLs display pleiotropic effects including antioxidant, anti-apoptotic, anti-inflammatory, anti-thrombotic or anti-proteolytic properties that account for their protective action on endothelial cells. Vasodilatation via production of nitric oxide is also a hallmark of HDL action on endothelial cells. Endothelial cells express receptors for apoA-I and HDLs that mediate intracellular signalling and potentially participate in the internalization of these particles. In this review, we will detail the different effects of HDLs on the endothelium in normal and pathological conditions with a particular focus on the potential use of HDL therapy to restore endothelial function and integrity.
摘要
高密度脂蛋白（HDLs）是一类颗粒的统称，其特征在于存在载脂蛋白 A-I（apoA-I），并具有将胆固醇从周围组织转运回肝脏的能力。除了这一功能外，HDLs 还具有多种效应，包括抗氧化、抗凋亡、抗炎、抗血栓形成或抗蛋白水解作用，这些效应解释了其对内皮细胞的保护作用。通过产生一氧化氮引起的血管舒张也是 HDL 对内皮细胞作用的一个标志。内皮细胞表达 apoA-I 和 HDLs 的受体，介导细胞内信号转导，并可能参与这些颗粒的内化。在这篇综述中，我们将详细描述 HDLs 在正常和病理条件下对内皮细胞的不同作用，特别关注 HDL 治疗恢复内皮功能和完整性的潜在用途。
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