Chemical Process Research and Development, Teva Pharmaceuticals, 383 Phoenixville Pike, Malvern, Pennsylvania 19355, United States.
Org Lett. 2013 Apr 5;15(7):1650-3. doi: 10.1021/ol400432x. Epub 2013 Mar 14.
An efficient, catalytic hypervalent iodine-mediated oxidative 1,2-shift of 1,1'-disubstituted olefins is described. This methodology provides concise access to homobenzylic ketones with electron-donating substituents. In the case of cyclic systems, this transformation results in ring-expanded β-benzocycloalkanones, which are useful for further elaboration.
描述了一种高效、催化的高价碘介导的 1,1'-取代烯烃的 1,2-迁移氧化反应。这种方法为具有给电子取代基的同苄基酮提供了简洁的合成途径。在环状体系的情况下，这种转化导致了环扩宽的β-苯并环烷酮，它们可用于进一步的修饰。
