使用芳基（碘）磺酸作为前催化剂和 Oxone 作为氧化剂，催化 1,1'-取代烯烃的 1,2-氧化迁移反应。
Catalytic oxidative 1,2-shift in 1,1'-disubstituted olefins using arene(iodo)sulfonic acid as the precatalyst and oxone as the oxidant.
机构信息
Chemical Process Research and Development, Teva Pharmaceuticals, 383 Phoenixville Pike, Malvern, Pennsylvania 19355, United States.
出版信息
Org Lett. 2013 Apr 5;15(7):1650-3. doi: 10.1021/ol400432x. Epub 2013 Mar 14.
PMID:23489019
Abstract
An efficient, catalytic hypervalent iodine-mediated oxidative 1,2-shift of 1,1'-disubstituted olefins is described. This methodology provides concise access to homobenzylic ketones with electron-donating substituents. In the case of cyclic systems, this transformation results in ring-expanded β-benzocycloalkanones, which are useful for further elaboration.
摘要
描述了一种高效、催化的高价碘介导的 1,1'-取代烯烃的 1,2-迁移氧化反应。这种方法为具有给电子取代基的同苄基酮提供了简洁的合成途径。在环状体系的情况下，这种转化导致了环扩宽的β-苯并环烷酮，它们可用于进一步的修饰。
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