澳大利亚海洋海绵 Pseudoceratina verrucosa 中的溴酪氨酸生物碱。

Bromotyrosine alkaloids from the Australian marine sponge Pseudoceratina verrucosa.

机构信息

Eskitis Institute, Griffith University, Brisbane, Queensland 4111, Australia.

出版信息

J Nat Prod. 2013 Apr 26;76(4):516-23. doi: 10.1021/np300648d. Epub 2013 Mar 14.

Abstract

Two new bromotyrosine alkaloids, pseudoceralidinone A (1) and aplysamine 7 (2), along with three known compounds were isolated from the Australian sponge Pseudoceratina verrucosa. Their structures were characterized by NMR and MS data and the synthetic route. Their cytotoxicity was evaluated against cancer cell lines (HeLa and PC3) and a noncancer cell line (NFF).

摘要

从澳大利亚海绵 Pseudoceratina verrucosa 中分离得到了两个新的溴酪氨酸生物碱，假珊瑚苷酮 A（1）和阿普利胺 7（2），以及三个已知化合物。通过 NMR 和 MS 数据以及合成路线确定了它们的结构。评估了它们对癌细胞系（HeLa 和 PC3）和非癌细胞系（NFF）的细胞毒性。