Institute of Medical Microbiology and Hygiene, Hermann-Herder-Strasse 11, D-79104 Freiburg, Germany.
Curr Opin Immunol. 2013 Apr;25(2):139-47. doi: 10.1016/j.coi.2013.02.007. Epub 2013 Mar 13.
Innate lymphoid cells (ILCs) are an emerging group of innate lymphocytes that share functional and transcriptional attributes with the various T helper cell effector fates (e.g. Th1, Th2, Th17). ILCs are substantially represented in the intestinal mucosa but are rare in secondary lymphoid organs. They play important roles in epithelial homeostasis, tissue repair and in immunity to intestinal infections. They are also involved in immune-mediated pathology. Here, we will review the emerging roles of the transcription factors T-bet and Gata3 in the development, lineage specification and function of distinct ILC lineages. We will also highlight the requirement of these transcriptional programs for the control of infections and the pathogenesis of inflammatory diseases.
先天淋巴细胞 (ILCs) 是一组新兴的先天淋巴细胞，它们在功能和转录特征上与各种辅助性 T 细胞效应命运（例如 Th1、Th2、Th17）共享。ILCs 在肠黏膜中大量存在，但在次级淋巴器官中很少见。它们在上皮细胞稳态、组织修复以及对肠道感染的免疫中发挥重要作用。它们也参与免疫介导的病理学。在这里，我们将回顾转录因子 T-bet 和 Gata3 在不同 ILC 谱系的发育、谱系特化和功能中的作用。我们还将强调这些转录程序对感染控制和炎症性疾病发病机制的重要性。
