Department of Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA.
Curr Opin Cell Biol. 2013 Aug;25(4):471-6. doi: 10.1016/j.ceb.2013.02.011. Epub 2013 Mar 13.
Both mitochondrial and cellular function are influenced by the overall structure and position of mitochondria within cells. Proper mitochondrial structure and position are achieved through the concerted actions of multiple activities. These include mitochondrial dynamics, motility and tethering. Mitochondrial dynamics and motility facilitate transport of the organelle, while tethering pathways serve to stably position mitochondria at specific cellular sites. Recent studies have advanced our understanding of the molecular mechanisms underlying the activities that shape and position the mitochondrial network and have identified the ER as an active participant in many of these activities.
线粒体和细胞功能都受到线粒体在细胞内的整体结构和位置的影响。适当的线粒体结构和位置是通过多种活动的协同作用实现的。这些活动包括线粒体动力学、运动和连接。线粒体动力学和运动促进细胞器的运输，而连接途径则将线粒体稳定地定位在特定的细胞部位。最近的研究提高了我们对塑造和定位线粒体网络的活动的分子机制的理解，并确定了内质网是许多这些活动的积极参与者。
