Munaro N I
Cátedra de Farmacología, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Argentina.
Pharmacol Biochem Behav. 1990 May;36(1):81-4. doi: 10.1016/0091-3057(90)90129-6.
Disruption of mother-pup interaction by pup deprivation induced an increase of glutamate decarboxylase (GAD) activity in the main and accessory olfactory bulbs (OB) of lactating rats. The presentation of pups to deprived mothers with restriction of suckling and tactile interaction decreased GAD activity in the main bulb to the levels of lactating rats. The accessory bulb enzymatic activity was similar to that of lactating rats when the pups were returned completely to deprived mothers. Deafferentation of OB did not modify the enzymatic activity in nonlactating rats. In lactating mothers deafferentation decreased GAD activity in the accessory OB compared to the main OB and also had less activity than the accessory OB mothers without deafferentation. Deafferentation in deprived mothers decreased GAD activity in both main and accessory OB. These results indicate a role for GABA neurotransmission in olfactory bulbs of lactating rats.
剥夺幼崽导致母婴互动中断，引起泌乳大鼠主嗅球和副嗅球中谷氨酸脱羧酶（GAD）活性增加。将幼崽呈现给被剥夺幼崽的母亲，并限制其哺乳和触觉互动，可使主嗅球中的GAD活性降至泌乳大鼠的水平。当幼崽完全回到被剥夺幼崽的母亲身边时，副嗅球的酶活性与泌乳大鼠相似。嗅球去传入神经对非泌乳大鼠的酶活性没有影响。在泌乳母亲中，与主嗅球相比，去传入神经使副嗅球中的GAD活性降低，且其活性也低于未去传入神经的副嗅球母亲。被剥夺幼崽的母亲去传入神经后，主嗅球和副嗅球中的GAD活性均降低。这些结果表明GABA神经传递在泌乳大鼠嗅球中发挥作用。
