Navarro Becerra N, Grigorjev C, Munaro N
Cátedra de Farmacología, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Argentina.
Eur J Pharmacol. 1996 Sep 19;312(1):83-7. doi: 10.1016/0014-2999(96)00447-5.
The effect of ovarian steroids and pheromones on the activity of glutamic acid decarboxylase, the enzyme that synthesizes gamma-aminobutyric acid (GABA), was studied in the rat olfactory bulbs. The enzyme activity was measured in the main and accessory olfactory bulbs at 11:00 h and 17:00 h in ovariectomized rats, and in rats treated with ovarian steroids or exposed to male pheromones. The enzyme activity in both bulbs showed a diurnal fluctuation that was not affected in the accessory bulbs by the exposure to pheromones while the rhythm disappeared in the main bulbs. Estrogen and estrogen-progesterone treatments decreased the enzyme activity in both bulbs either in the morning or in the afternoon. The exposure of ovariectomized estrogen-primed rats to male pheromones reversed the effect of estrogen on the enzyme activity in the morning but not in the afternoon. Ovarian hormones plus pheromones prevented the steroid effect only in the morning. These results support the view that in olfactory bulbs, the GABAergic system can be modulated by endocrine and pheromonal factors.
在大鼠嗅球中研究了卵巢甾体激素和信息素对谷氨酸脱羧酶（合成γ-氨基丁酸（GABA）的酶）活性的影响。在11:00和17:00测量了去卵巢大鼠、接受卵巢甾体激素治疗或暴露于雄性信息素的大鼠主嗅球和副嗅球中的酶活性。两个嗅球中的酶活性均呈现昼夜波动，暴露于信息素对副嗅球的这种波动没有影响，而主嗅球中的节律消失。雌激素和雌激素-孕酮治疗在上午或下午均降低了两个嗅球中的酶活性。去卵巢并用雌激素预处理的大鼠暴露于雄性信息素后，在上午逆转了雌激素对酶活性的影响，但下午没有。卵巢激素加信息素仅在上午阻止了甾体激素的作用。这些结果支持这样一种观点，即在嗅球中，GABA能系统可受内分泌和信息素因素调节。
