School of Engineering, Brown University, Providence, RI, USA.
Int J Nanomedicine. 2013;8:995-1001. doi: 10.2147/IJN.S38500. Epub 2013 Mar 6.
Cervical cancer can be treated by surgical resection, chemotherapy, and/or radiation. Titanium biomaterials have been suggested as a tool to help in the local delivery of chemotherapeutic agents and/or radiation to cervical cancer sites. However, current titanium medical devices used for treating cervical cancer do not by themselves possess any anticancer properties; such devices act as carriers for pharmaceutical agents or radiation sources and may even allow for the growth of cancer cells. Based on studies, which have demonstrated decreased lung, breast, and bone cancer cell functions on nanostructured compared to nanosmooth polymers, the objective of the present in vitro study was to modify titanium to possess nanotubular surface features and determine cervical cancer cell adhesion after 4 hours. Here, titanium was anodized to possess nanotubular surface features. Results demonstrated the ability to decrease cervical cancer cell adhesion by about a half on nanotubular compared to currently used nanosmooth titanium (without the use of chemotherapeutics or radiation), opening up numerous possibilities for the use of nanotubular titanium in local drug delivery or radiation treatment of cervical cancer.
宫颈癌可以通过手术切除、化疗和/或放疗来治疗。钛生物材料已被提议作为一种工具，以帮助将化疗药物和/或辐射局部递送到宫颈癌部位。然而，目前用于治疗宫颈癌的钛医疗器械本身并不具有抗癌特性；这些设备充当药物或放射源的载体，甚至可能允许癌细胞生长。基于研究表明，与纳米光滑聚合物相比，纳米结构降低了肺癌、乳腺癌和骨癌细胞的功能，本体外研究的目的是修饰钛以具有纳米管状表面特征，并确定 4 小时后宫颈癌细胞的黏附。在这里，钛经过阳极氧化处理，具有纳米管状表面特征。结果表明，与目前使用的纳米光滑钛（不使用化疗药物或放射治疗）相比，纳米管可以将宫颈癌细胞的黏附减少约一半，为纳米管钛在宫颈癌的局部药物输送或放射治疗中的应用开辟了许多可能性。
