Kerl Hans U, Gerigk Lars, Brockmann Marc A, Huck Sonia, Al-Zghloul Mansour, Groden Christoph, Hauser Thomas, Nagel Armin M, Nölte Ingo S
Hans U Kerl, Marc A Brockmann, Sonia Huck, Mansour Al-Zghloul, Christoph Groden, Ingo S Nölte, Department of Neuroradiology, University Medical Center Mannheim, University of Heidelberg, 68167 Mannheim, Germany.
World J Radiol. 2013 Jan 28;5(1):5-16. doi: 10.4329/wjr.v5.i1.5.
To evaluate different promising magnetic resonance imaging (MRI) methods at 7.0 Tesla (T) for the pre-stereotactic visualization of the zona incerta (ZI).
Two neuroradiologists qualitatively and quantitatively examined T2-turbo spin-echo (T2-TSE), T1-weighted gradient-echo, as well as FLASH2D-T2Star and susceptibility-weighted imaging (SWI) for the visualization of the ZI at 7.0 T MRI. Delineation and image quality for the ZI were independently examined using a 6-scale grading system. Inter-rater reliability using Cohen's kappa coefficient (κ) were assessed. Contrast-to-noise ratios (CNR), and signal-to-noise ratios (SNR) for the ZI were calculated for all sequences. Differences in delineation, SNR, and CNR between the sequences were statistically assessed using a paired t-test. For the anatomic validation the coronal FLASH2D-T2Star images were co-registered with a stereotactic atlas (Schaltenbrand-Wahren).
The rostral part of the ZI (rZI) could easily be identified and was best and reliably visualized in the coronal FLASH2D-T2Star images. The caudal part was not definable in any of the sequences. No major artifacts in the rZI were observed in any of the scans. FLASH2D-T2Star and SWI imaging offered significant higher CNR values for the rZI compared to T2-TSE images (P > 0.05). The co-registration of the coronal FLASH2D-T2Star images with the stereotactic atlas schema (Schaltenbrand-Wahren) confirmed the correct localization of the ZI in all cases.
FLASH2D-T2Star imaging (particularly coronal view) provides the reliable and currently optimal visualization of the rZI at 7.0 T. These results can facilitate a better and more precise targeting of the caudal part of the ZI than ever before.
评估7.0特斯拉（T）下不同的有前景的磁共振成像（MRI）方法用于未定带（ZI）立体定向术前可视化。
两名神经放射科医生对7.0 T MRI下用于ZI可视化的T2加权快速自旋回波（T2-TSE）、T1加权梯度回波以及FLASH2D-T2Star和磁敏感加权成像（SWI）进行定性和定量检查。使用6级评分系统独立检查ZI的勾画和图像质量。使用科恩kappa系数（κ）评估评分者间信度。计算所有序列的ZI的对比噪声比（CNR）和信噪比（SNR）。使用配对t检验对序列间在勾画、SNR和CNR方面的差异进行统计学评估。为进行解剖学验证，将冠状位FLASH2D-T2Star图像与立体定向图谱（Schaltenbrand-Wahren）进行配准。
ZI的嘴侧部分（rZI）很容易识别，并且在冠状位FLASH2D-T2Star图像中显示最佳且最可靠。在任何序列中均无法明确界定尾侧部分。在任何扫描中均未在rZI中观察到主要伪影。与T2-TSE图像相比，FLASH2D-T2Star和SWI成像为rZI提供了显著更高的CNR值（P>0.05）。冠状位FLASH2D-T2Star图像与立体定向图谱模式（Schaltenbrand-Wahren）的配准在所有病例中均证实了ZI的正确定位。
FLASH2D-T2Star成像（特别是冠状位视图）在7.0 T时能可靠且目前最优地显示rZI。这些结果可促进比以往更好、更精确地靶向ZI的尾侧部分。
