Department of Pharmacology and Clinical Neuroscience, Division of Neurosurgery, Umeå University, Umeå, Sweden.
Acta Neurochir (Wien). 2012 Mar;154(3):495-9. doi: 10.1007/s00701-011-1230-z. Epub 2011 Nov 23.
Essential tremor (ET) is the most common movement disorder and often affects the quality of life. There are only a few studies evaluating the quality of life after deep brain stimulation (DBS).
This is a prospective study of 16 patients undergoing deep brain stimulation in the caudal Zona incerta (cZi). The quality of life was assessed with Quality of Life in Essential Tremor Questionnaire (QUEST) and SF-36 scores, and the tremor was evaluated using the essential tremor rating scale (ETRS).
In the tremor rating, hand tremor on the treated side improved by 95%, hand function by 78% and activities of daily living by 71%. The QUEST score showed statistically significant improvements in the psychosocial and activities of daily living subscores. The SF-36 score did not show any significant improvement.
Although very good tremor reduction was achieved, the improvement in the quality of life scores was more modest. This could partly be explained by the quality of life being affected by other factors than the tremor itself.
特发性震颤（ET）是最常见的运动障碍，常影响生活质量。仅有少数研究评估了深部脑刺激（DBS）后的生活质量。
这是一项对 16 例接受尾状核下区（cZi）深部脑刺激的患者进行的前瞻性研究。采用特发性震颤生活质量问卷（QUEST）和 SF-36 评分评估生活质量，采用特发性震颤评定量表（ETRS）评估震颤。
在震颤评定中，治疗侧手震颤改善 95%，手功能改善 78%，日常生活活动改善 71%。QUEST 评分在心理社会和日常生活活动亚量表上有统计学意义的改善。SF-36 评分没有显著改善。
虽然震颤得到了非常好的减轻，但生活质量评分的改善更为适度。这部分可以通过生活质量受震颤本身以外的其他因素影响来解释。
