Erren Thomas C, Reiter Russel J
Institute and Policlinic for Occupational Medicine, Environmental Medicine, and Prevention Research, University of Cologne, Lindenthal, Cologne, Germany.
Naturwissenschaften. 2013 Apr;100(4):291-8. doi: 10.1007/s00114-013-1026-5. Epub 2013 Mar 14.
In this Concepts & Synthesis paper, we expand the definition of chronodisruption in humans by proposing that it can be operationalized as the split nexus of internal and external times. With this premise, we suggest how chronotype may be used as a temporal marker (chronomarker) of exposure to chronodisruption in studies of cancer, and beyond, offer cancer risk predictions for observational research on the basis of a chronotype-related hypothesis and corollary, and point to first empirical data in humans. In an a priori way, we examine possible outcomes and perspectives for preventive measures following from our rationale and the suggested chronobiology-driven studies and close with overall advances of chronodisruption research.
在这篇概念与综述论文中，我们拓展了人类生物钟紊乱的定义，提出它可被定义为内部时间与外部时间的分裂联系。基于这一前提，我们建议在癌症研究及其他领域中，如何将昼夜节律类型用作生物钟紊乱暴露的时间标记（时间标记物），基于与昼夜节律类型相关的假设和推论为观察性研究提供癌症风险预测，并指出人类的首批实证数据。我们以先验的方式研究了基于我们的理论依据以及所建议的生物钟学驱动研究的预防措施可能产生的结果和前景，并以生物钟紊乱研究的总体进展作为结尾。
