Tanabayashi K, Takeuchi K, Hishiyama M, Yamada A, Sugiura A
Department of Measles Virus, National Institute of Health, Tokyo, Japan.
Virus Genes. 1990 Apr;3(4):361-5. doi: 10.1007/BF00569042.
The nucleotide sequence of the gene encoding the matrix (M) protein of mumps virus (MuV), Miyahara strain, has been determined from several overlapping cDNA clones. The M protein mRNA is 1248 nucleotides in length, exclusive of the poly(A) tail, and codes for a protein of 375 amino acids (Mr41,556). Comparison of the deduced amino acid sequence of the M protein of the Miyahara strain with that of the SBL-1 strain revealed that the M proteins of both strains are highly conserved. A significantly lower rate of nucleotide differences conducive to amino acid differences in the M gene compared with other genes appeared to indicate the importance of the conserved primary structure of the M protein for its function.
通过几个重叠的cDNA克隆，已确定了腮腺炎病毒（MuV）宫原株编码基质（M）蛋白的基因的核苷酸序列。M蛋白mRNA长度为1248个核苷酸，不包括聚腺苷酸尾，编码一个由375个氨基酸组成的蛋白质（Mr41,556）。将宫原株M蛋白的推导氨基酸序列与SBL-1株的进行比较，发现两株的M蛋白高度保守。与其他基因相比，M基因中导致氨基酸差异的核苷酸差异率显著较低，这似乎表明M蛋白保守的一级结构对其功能很重要。
