National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Cell. 2013 Mar 14;152(6):1209-12. doi: 10.1016/j.cell.2013.02.048.
The recent ability to routinely probe genome function at a global scale has revolutionized our view of genomes. One of the most important realizations from these approaches is that the functional output of genomes is affected by the nuclear environment in which they exist. Integration of sequence information with molecular and cellular features of the genome promises a fuller understanding of genome function.
近年来，人们能够常规地在全基因组范围内探测基因组功能，这一技术的发展彻底改变了我们对基因组的认识。这些方法中最重要的发现之一是，基因组的功能输出受到其所处的核环境的影响。将序列信息与基因组的分子和细胞特征相结合，有望更全面地了解基因组功能。
