Berseth C L, Michener S R, Nordyke C K, Go V L
Department of Pediatrics, Mayo Clinic, Rochester, MN 55905.
Am J Clin Nutr. 1990 Jun;51(6):985-90. doi: 10.1093/ajcn/51.6.985.
Concentrations of gastrointestinal neuropeptides in serial human milk samples from 28 women were determined over the first 6 postpartum mo. All gut neuropeptides were present during the first postpartum week. Gastric inhibitory peptide (GIP) concentration remained constant but the others decreased by 6 wk. Bombesin concentration in breast milk was threefold greater than concurrent plasma concentration (p less than 0.001); all other neuropeptides were at the same or lower concentrations in milk than in plasma. At 36 wk gestation plasma concentrations of GIP were lower and concentrations of vasoactive intestinal peptide were higher than concentrations in age-matched control subjects. Concentrations of gastrin and cholecystokinin, bombesin, peptide histidine methionine, peptide YY, and neurotensin in plasma were similar in pregnant and nonpregnant women. These gut neuropeptides in milk may be important for growth and maturation of the gastrointestinal system in neonates. Bombesin may contribute to neonatal hypergastrinemia.
对28名女性产后头6个月内采集的系列母乳样本中的胃肠神经肽浓度进行了测定。所有肠道神经肽在产后第一周均存在。胃抑制肽（GIP）浓度保持恒定，但其他神经肽在产后6周时浓度下降。母乳中蛙皮素的浓度比同期血浆浓度高两倍（p<0.001）；所有其他神经肽在母乳中的浓度与血浆浓度相同或更低。妊娠36周时，GIP的血浆浓度低于年龄匹配的对照受试者，而血管活性肠肽的浓度高于对照受试者。孕妇和非孕妇血浆中胃泌素、胆囊收缩素、蛙皮素、肽组氨酸甲硫氨酸、肽YY和神经降压素的浓度相似。母乳中的这些肠道神经肽可能对新生儿胃肠道系统的生长和成熟很重要。蛙皮素可能导致新生儿高胃泌素血症。
