Medical Informatics and Biological Micro-electro-mechanical Systems Specialized Laboratory, Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, Kuala Lumpur, Malaysia.
PLoS One. 2013;8(3):e58523. doi: 10.1371/journal.pone.0058523. Epub 2013 Mar 11.
This paper introduces novel vacuum/compression valves (VCVs) utilizing paraffin wax. A VCV is implemented by sealing the venting channel/hole with wax plugs (for normally-closed valve), or to be sealed by wax (for normally-open valve), and is activated by localized heating on the CD surface. We demonstrate that the VCV provides the advantages of avoiding unnecessary heating of the sample/reagents in the diagnostic process, allowing for vacuum sealing of the CD, and clear separation of the paraffin wax from the sample/reagents in the microfluidic process. As a proof of concept, the microfluidic processes of liquid flow switching and liquid metering is demonstrated with the VCV. Results show that the VCV lowers the required spinning frequency to perform the microfluidic processes with high accuracy and ease of control.
本文介绍了利用石蜡的新型真空/压缩阀 (VCV)。VCV 通过用蜡塞密封通气通道/孔（用于常闭阀），或通过蜡密封（用于常开阀），并通过在 CD 表面局部加热来实现。我们证明，VCV 具有避免在诊断过程中不必要地加热样品/试剂、允许对 CD 进行真空密封以及在微流控过程中使石蜡与样品/试剂清晰分离的优点。作为概念验证，使用 VCV 演示了微流控过程中的液体流量切换和液体计量。结果表明，VCV 降低了执行微流控过程所需的旋转频率，从而实现了高精度和易于控制。
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