Medical Informatics and Biological Micro-electro-mechanical Systems (MIMEMS) Specialized Laboratory, Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, Malaysia.
Med Biol Eng Comput. 2013 May;51(5):525-35. doi: 10.1007/s11517-012-1020-7. Epub 2013 Jan 6.
This paper presents a theoretical development and critical analysis of the burst frequency equations for capillary valves on a microfluidic compact disc (CD) platform. This analysis includes background on passive capillary valves and the governing models/equations that have been developed to date. The implicit assumptions and limitations of these models are discussed. The fluid meniscus dynamics before bursting is broken up into a multi-stage model and a more accurate version of the burst frequency equation for the capillary valves is proposed. The modified equations are used to evaluate the effects of various CD design parameters such as the hydraulic diameter, the height to width aspect ratio, and the opening wedge angle of the channel on the burst pressure.
本文提出了一种对微流控光盘（CD）平台上毛细阀的突发频率方程的理论发展和批判性分析。该分析包括被动毛细阀的背景以及迄今为止已经开发的控制模型/方程。讨论了这些模型的隐含假设和局限性。在爆裂之前，将流体弯月面动力学分解为多阶段模型，并提出了毛细阀的更准确的突发频率方程。使用修改后的方程来评估各种 CD 设计参数（例如水力直径、高度与宽度的纵横比以及通道的开口楔形角）对破裂压力的影响。
