Maquet P, Dive D, Salmon E, Sadzot B, Franco G, Poirrier R, Franck G
Department of Neurology, University of Liège, CHU Sart Tilman, Belgium.
Brain Res. 1992 Jan 31;571(1):149-53. doi: 10.1016/0006-8993(92)90522-b.
Using [18F]fluorodeoxyglucose method and positron emission tomography, we performed paired determinations of the cerebral glucose utilization at one week intervals during sleep and wakefulness, in 12 young normal subjects. During 6 of 28 sleep runs, a stable stage 2 SWS was observed that fulfilled the steady-state conditions of the model. The cerebral glucose utilization during stage 2 SWS was lower than during wakefulness, but the variation did not significantly differ from zero (mean variation: -11.5 +/- 25.57%, P = 0.28). The analysis of 89 regions of interest showed that glucose metabolism differed significantly from that observed at wake in 6 brain regions, among them both thalamic nuclei. We conclude that the brain energy metabolism is not homogeneous throughout all the stages of non-REMS but decreases from stage 2 SWS to deep SWS; we suggest that a low thalamic glucose metabolism is a metabolic feature common to both stage 2 and deep SWS, reflecting the inhibitory processes observed in the thalamus during these stages of sleep. Stage 2 SWS might protect the stability of sleep by insulating the subject from the environment and might be a prerequisite to the full development of other phases of sleep, especially deep SWS.
我们采用[18F]氟脱氧葡萄糖法和正电子发射断层扫描技术，对12名年轻正常受试者在睡眠和清醒状态下每隔一周进行一次大脑葡萄糖利用情况的配对测定。在28次睡眠测试中的6次中，观察到一个稳定的2期慢波睡眠阶段，该阶段满足模型的稳态条件。2期慢波睡眠期间的大脑葡萄糖利用率低于清醒期间，但变化与零无显著差异（平均变化：-11.5±25.57%，P = 0.28）。对89个感兴趣区域的分析表明，6个脑区的葡萄糖代谢与清醒时观察到的情况有显著差异，其中包括两个丘脑核。我们得出结论，在非快速眼动睡眠的所有阶段，大脑能量代谢并非均匀一致，而是从2期慢波睡眠到深度慢波睡眠逐渐降低；我们认为丘脑葡萄糖代谢降低是2期和深度慢波睡眠共有的代谢特征，反映了在这些睡眠阶段丘脑中观察到的抑制过程。2期慢波睡眠可能通过使受试者与环境隔绝来保护睡眠的稳定性，并且可能是睡眠其他阶段充分发展的先决条件，尤其是深度慢波睡眠。
