Yamaguchi K, Hama H, Adachi C
Department of Physiology, Niigata University School of Medicine, Japan.
Brain Res. 1990 Apr 16;513(2):335-8. doi: 10.1016/0006-8993(90)90477-s.
Acute blood loss (16 ml/kg b. wt.) in conscious rats caused, 5 min later, increases in plasma vasopressin (AVP) concentration accompanied by reductions in arterial pressure and hematocrit. The plasma AVP response was markedly enhanced by intracerebroventricular injection (10 microliters) of a dopamine antagonist, haloperidol (0.15 mumol), which did not affect the responses of arterial pressure and hematocrit significantly. These results suggest that periventricular dopaminergic mechanisms may act to inhibit hemorrhage-induced AVP secretion.
清醒大鼠急性失血（16毫升/千克体重）5分钟后，血浆血管加压素（AVP）浓度升高，同时动脉血压和血细胞比容降低。脑室内注射（10微升）多巴胺拮抗剂氟哌啶醇（0.15微摩尔）可显著增强血浆AVP反应，而对动脉血压和血细胞比容的反应无明显影响。这些结果表明，脑室周围多巴胺能机制可能起到抑制出血诱导的AVP分泌的作用。
