Academic Department of Paediatrics, Imperial College London, London, UK.
Curr Opin Infect Dis. 2013 Jun;26(3):248-53. doi: 10.1097/QCO.0b013e3283607a58.
Following on from the success of maternal tetanus vaccination, recent research has shown that other vaccines given in pregnancy can protect against vaccine-preventable infections in early infancy. This review will outline these recent developments and highlight the impact on current clinical practice.
Maternal immunization provides protection to the newborn through the transfer of vaccine-induced IgG across the placenta, a process that is affected by multiple variables. The safety of newly recommended maternal vaccines has been further tested in recent studies. Maternal vaccination against influenza and pertussis is recommended in the United Kingdom and United States, with new studies indicating their efficacy. A number of additional maternal vaccines are also in the pipeline, which could be used to combat neonatal infection. Recent research findings have highlighted some of the reasons for the poor uptake of current recommendations among pregnant women.
Tetanus, influenza and pertussis vaccines are now recommended for use during pregnancy, with new vaccines, such as group B streptococcus and respiratory syncytial virus, being developed to prevent important neonatal infections in the future.
继母体破伤风疫苗接种取得成功之后，最近的研究表明，孕妇接种其他疫苗也可以预防婴儿早期的疫苗可预防感染。本综述将概述这些最新进展，并强调其对当前临床实践的影响。
母体免疫通过将疫苗诱导的 IgG 穿过胎盘转移到新生儿中提供保护，该过程受多种变量的影响。最近的研究进一步测试了新推荐的母体疫苗的安全性。在美国和英国，建议孕妇接种流感和百日咳疫苗，新的研究表明它们具有疗效。还有一些其他的母体疫苗也在研发中，可用于预防新生儿感染。最近的研究结果强调了目前孕妇对这些建议的接受率低的部分原因。
破伤风、流感和百日咳疫苗现在已被推荐在怀孕期间使用，新的疫苗，如 B 型链球菌和呼吸道合胞病毒，正在开发中，以预防未来重要的新生儿感染。
