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[喉癌前病变及喉癌的治疗]

[Treatment of precanceroses and carcinoma of the larynx].

作者信息

Tocík J

机构信息

Katedra otorinolaryngológie LF UK, Bratislava.

出版信息

Cesk Otolaryngol. 1990 Apr;39(2):76-83.

PMID:2350808
Abstract

The problem of diagnosis and treatment of precanceroses and carcinome of the larynx is still one of the foremost interests of ENT specialists. In 1973 to 1982 82 patients with precanceroses of the larynx and 174 patients with carcinoma of the larynx were detected and treated. In the treatment of precanceroses of the larynx the laryngomicro-surgical procedure proved useful. In the third stage of Reinke's oedema a satisfactory functional effect was achieved in 100%, in solitary papilloma and papillomatosis in 88%, in leukoplakia and pachyderma in 76% and in chronic hyperplastic in 67%. Least relapses were recorded in the third stage of Reinke's oedema (0%) and in chronic hyperplastic laryngitis (23%). In the treatment of carcinoma of the larynx combined surgical and radiation therapy is preferable and was used in 55.4% patients; in 36.9% patients only irradiation was used and in 7.7% patients only surgical treatment. Within the framework of surgical and combined treatment 52.8% patients were subjected to laryngectomy and 47.2% to various types of partial resections of the larynx. By combined treatment five-year survival was achieved in 67.5% patients; in stage I and II of carcinoma in as many as 87.5% and in stage III and IV only in 47.5%. In patients after actinotherapy five-year survival was attained only in 45% of the patients, and in those with a supraglottic localization of the tumour only in 30%.

摘要

喉癌前病变和喉癌的诊断与治疗问题仍然是耳鼻喉科专家最关注的问题之一。1973年至1982年期间,共检测并治疗了82例喉癌前病变患者和174例喉癌患者。在喉癌前病变的治疗中,喉显微外科手术被证明是有效的。在Reinke水肿的第三阶段,100%的患者获得了满意的功能效果;孤立性乳头状瘤和乳头状瘤病患者为88%,白斑病和厚皮病患者为76%,慢性增生性病变患者为67%。Reinke水肿第三阶段(0%)和慢性增生性喉炎(23%)的复发率最低。在喉癌的治疗中,手术和放疗联合治疗更为可取,55.4%的患者采用了这种方法;36.9%的患者仅接受了放疗,7.7%的患者仅接受了手术治疗。在手术和联合治疗的框架内,52.8%的患者接受了喉切除术,47.2%的患者接受了各种类型的喉部部分切除术。通过联合治疗,67.5%的患者实现了五年生存率;在癌的I期和II期,这一比例高达87.5%,而在III期和IV期,仅为47.5%。在接受放疗的患者中,只有45%的患者实现了五年生存率,而肿瘤位于声门上的患者中,这一比例仅为30%。

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