Department of Mechanical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA.
Ann Biomed Eng. 2013 Jul;41(7):1459-77. doi: 10.1007/s10439-013-0786-6. Epub 2013 Mar 19.
The current clinical management of abdominal aortic aneurysm (AAA) disease is based to a great extent on measuring the aneurysm maximum diameter to decide when timely intervention is required. Decades of clinical evidence show that aneurysm diameter is positively associated with the risk of rupture, but other parameters may also play a role in causing or predisposing the AAA to rupture. Geometric factors such as vessel tortuosity, intraluminal thrombus volume, and wall surface area are implicated in the differentiation of ruptured and unruptured AAAs. Biomechanical factors identified by means of computational modeling techniques, such as peak wall stress, have been positively correlated with rupture risk with a higher accuracy and sensitivity than maximum diameter alone. The objective of this review is to examine these factors, which are found to influence AAA disease progression, clinical management and rupture potential, as well as to highlight on-going research by our group in aneurysm modeling and rupture risk assessment.
目前，腹主动脉瘤（AAA）疾病的临床管理在很大程度上依赖于测量动脉瘤最大直径来决定何时需要及时干预。几十年来的临床证据表明，动脉瘤直径与破裂风险呈正相关，但其他参数也可能在导致或易患 AAA 破裂方面发挥作用。几何因素，如血管迂曲、管腔内血栓体积和管壁表面积，与破裂和未破裂的 AAA 之间存在差异。通过计算建模技术确定的生物力学因素，如峰值壁应力，与破裂风险呈正相关，其准确性和灵敏度均高于单纯最大直径。本综述的目的是检查这些因素，这些因素被发现会影响 AAA 疾病的进展、临床管理和破裂潜力，并强调我们小组在动脉瘤建模和破裂风险评估方面的正在进行的研究。
