Garg M K, Marwaha Raman K, Khadgawat Rajesh, Ramot Rekha, Obroi Avneet Kaur, Mehan Neena, Gupta Nandita, Madan Renu
Army Hospital (Research and Referral), Delhi Cantonment, Delhi, India.
J Pediatr Endocrinol Metab. 2013;26(5-6):515-23. doi: 10.1515/jpem-2012-0390.
Vitamin D deficiency (VDD) among adolescents is a major health problem in India. The aim of this study was to assess the efficacy of therapeutic/loading doses of vitamin D supplementation on serum 25-hydroxy vitamin D (25OHD) levels in vitamin D deficient adolescents.
A total of 482 out of the 511 subjects recruited for the study were divided into three groups, each group receiving 60,000 IU of vitamin D3 weekly for 4, 6 and 8 weeks followed by 600 IU daily for 12 weeks, respectively. Clinical evaluation was followed by estimation of biochemical markers and serum 25OHD levels.
VDD was observed in 94.8% of adolescents. All three vitamin D loading doses were equally efficacious in achieving vitamin D sufficiency >75 nmol/L (>30 ng/mL) in more than 90% subjects in the three groups. Mean 25OHD levels in groups 2 and 3 following maintenance therapy were 67.5±16.5 nmol/L (27.0±6.6 ng/mL) and 70.0±21.8 nmol/L (28.0±8.7 ng/mL), respectively.
Supplementing 60,000 IU of vitamin D3 per week for 4-8 weeks, followed by 600 IU daily through fortified milk, is an effective strategy for achieving vitamin D sufficiency in Indian adolescents.
青少年维生素D缺乏（VDD）是印度的一个主要健康问题。本研究的目的是评估治疗/负荷剂量的维生素D补充剂对维生素D缺乏青少年血清25-羟基维生素D（25OHD）水平的疗效。
本研究招募的511名受试者中，共有482人被分为三组，每组分别每周接受60,000 IU维生素D3，持续4、6和8周，随后每天接受600 IU，持续12周。进行临床评估后，测定生化标志物和血清25OHD水平。
94.8%的青少年存在VDD。三组中超过90%的受试者使用的三种维生素D负荷剂量在使维生素D充足水平>75 nmol/L（>30 ng/mL）方面同样有效。维持治疗后，第2组和第3组的平均25OHD水平分别为67.5±16.5 nmol/L（27.0±6.6 ng/mL）和70.0±21.8 nmol/L（28.0±8.7 ng/mL）。
每周补充60,000 IU维生素D3，持续4 - 8周，随后通过强化牛奶每天补充600 IU，是使印度青少年达到维生素D充足水平的有效策略。
