Centre for Brain Research, Indian Institute of Science, Bangalore, India.
Front Public Health. 2021 Sep 3;9:707036. doi: 10.3389/fpubh.2021.707036. eCollection 2021.
The important role of micronutrient deficiencies in aging-related disorders including dementia is becoming increasingly evident. However, information on their burden in India is scarce, especially, among aging and rural communities. Prevalence of vitamin D, B12 and folic acid deficiency was measured in an ongoing, aging cohort, from rural India-Srinivaspura Aging Neurosenescence and COGnition (SANSCOG) study cohort. Serum level estimation of vitamin D, B12 and folic acid, using chemiluminescence immunoassay, was performed on 1648 subjects (872 males, 776 females). Mean vitamin D, B12 and folic acid levels were 23.4 ± 10.6 ng/ml, 277.4 ± 194.4 pg/ml and 6 ± 3.5 ng/ml), respectively. Prevalence of low vitamin D (<30 ng/ml), vitamin D deficiency (<20 ng/ml), B12 deficiency (<200 pg/ml) and folic acid deficiency (<3 ng/ml) were 75.7, 39.1, 42.3, and 11.1%, respectively. Significantly more women had vitamin D deficiency, whereas more men had folic acid deficiency. Women belonging to the oldest age group (≥75 years) had the maximum burden of low vitamin D (94.3%) and folic acid deficiency (21.8%). Older, rural-dwelling Indians have high burden of vitamin D and B12 deficiencies, which is concerning given the potentially negative consequences on cognition, immunity and frailty in the aging population. Urgent public health strategies are needed to address this issue and prevent or mitigate adverse consequences.
微量营养素缺乏在与衰老相关的疾病中起着重要作用，包括痴呆症。然而，关于其在印度的负担的信息很少，尤其是在老龄化和农村社区。我们在印度农村的 Srinivaspura 衰老神经衰老和认知 (SANSCOG) 研究队列中，对正在进行的衰老队列进行了维生素 D、B12 和叶酸缺乏症的患病率研究。使用化学发光免疫测定法对 1648 名受试者 (872 名男性，776 名女性) 的血清维生素 D、B12 和叶酸水平进行了估计。维生素 D、B12 和叶酸的平均水平分别为 23.4 ± 10.6 ng/ml、277.4 ± 194.4 pg/ml 和 6 ± 3.5 ng/ml)。维生素 D 水平低(<30ng/ml)、维生素 D 缺乏(<20ng/ml)、B12 缺乏(<200pg/ml)和叶酸缺乏(<3ng/ml)的患病率分别为 75.7%、39.1%、42.3%和 11.1%。女性维生素 D 缺乏症的比例明显更高，而男性叶酸缺乏症的比例更高。属于年龄最大组 (≥75 岁) 的女性维生素 D (94.3%)和叶酸缺乏症 (21.8%)的负担最大。年龄较大、居住在农村的印度人维生素 D 和 B12 缺乏的负担很重，考虑到其对衰老人群认知、免疫和虚弱的潜在负面影响，这令人担忧。需要紧急采取公共卫生策略来解决这个问题，以防止或减轻不良后果。
