School of Life Sciences, The Chinese University of Hong Kong, New Territories, Hong Kong.
Biomed Res Int. 2013;2013:916819. doi: 10.1155/2013/916819. Epub 2013 Jan 30.
Ovarian cancer is a highly lethal disease among all gynecologic malignancies and is the fifth leading cause of cancer-related death in women. Although the standard combination of surgery and chemotherapy was initially effective in patients with ovarian cancer, disease relapse commonly occurred due to the generation of chemoresistance. It has been reported that cancer stem cells (CSCs) are involved in drug resistance and cancer recurrence. Over the past decades, increasing studies have been done to identify CSCs from human ovarian cancer cells. The present paper will summarize different investigations on ovarian CSCs, including isolation, mechanisms of chemoresistance, and therapeutic approaches. Although there are still numerous challenges to translate basic research to clinical applications, understanding the molecular details of CSCs is essential for developing effective strategies to prevent ovarian cancer and its recurrence.
卵巢癌是妇科恶性肿瘤中致死率极高的一种疾病，也是女性癌症相关死亡的第五大主要原因。尽管手术和化疗的标准联合最初对卵巢癌患者有效，但由于产生了化疗耐药性，疾病常常会复发。据报道，癌症干细胞（CSCs）与耐药性和癌症复发有关。在过去的几十年中，已经有越来越多的研究致力于从人卵巢癌细胞中鉴定出 CSCs。本文将总结关于卵巢 CSCs 的不同研究，包括其分离、耐药机制和治疗方法。尽管将基础研究转化为临床应用仍然存在许多挑战，但了解 CSCs 的分子细节对于制定预防卵巢癌及其复发的有效策略至关重要。
