Center for Family Medicine, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden; Department of Public Health and Caring Sciences/Section of Geriatrics Uppsala University, Uppsala, Sweden.
Obesity (Silver Spring). 2014 Feb;22(2):526-9. doi: 10.1002/oby.20434. Epub 2013 Jun 13.
To investigate the association between hypertriglyceridemic waist (HTGW) and insulin sensitivity (assessed by euglycemic clamp method), and the development of diabetes in a longitudinal community-based cohort of elderly men without diabetes at baseline.
The present cross-sectional study comprised 1,026, 70-year-old men without diabetes. The gold standard euglycaemic-hyperinsulinaemic clamp technique was used. Six-year follow-up on diabetes status were available in n = 667. The HTGW phenotype was defined as having waist circumference ≥ 90 cm, and triglycerides ≥ 2 mmol L⁻¹. The men were stratified into those having normal WC and TG (n = 299), one HTGW component (n = 606), and HTGW (n = 121).
The association between insulin sensitivity and one HTGW component as well as HTGW was highly significant (P < 0.001) in the whole sample, as well as in individuals with high/low BMI (stratified at ≥25). In longitudinal analyses, participants with HTGW was associated with a more than fourfold increased risk for diabetes (Odds ratio 4.64, 95% CI 1.61-13.4, P = 0.004) compared to those with normal WC and TG.
The present study both confirm and extend previous research suggesting that the HTGW-phenotype portrays an increased glucometabolic risk, also in lean individuals.
在一项针对无糖尿病的老年男性的基于社区的纵向队列研究中，调查高甘油三酯性腰围（HTGW）与胰岛素敏感性（通过葡萄糖钳夹法评估）之间的关系，以及 HTGW 与糖尿病发病之间的关系。
本横断面研究纳入了 1026 名 70 岁的无糖尿病男性。使用金标准的葡萄糖-高胰岛素钳夹技术。在 n = 667 名参与者中，有 6 年的糖尿病发病情况随访。HTGW 表型定义为腰围≥90cm，甘油三酯≥2mmol/L。将男性分为正常 WC 和 TG（n = 299）、具有一个 HTGW 成分（n = 606）和 HTGW（n = 121）的个体。
在整个样本中，以及在 BMI 较高/较低（≥25）的个体中，胰岛素敏感性与一个 HTGW 成分以及 HTGW 之间的关系具有高度显著性（P < 0.001）。在纵向分析中，与具有正常 WC 和 TG 的个体相比，具有 HTGW 的个体患糖尿病的风险增加了四倍以上（比值比 4.64，95%置信区间 1.61-13.4，P = 0.004）。
本研究既证实了又扩展了先前的研究结果，表明 HTGW 表型增加了糖代谢风险，即使在瘦个体中也是如此。
