Key Laboratory of Molecular Epidemiology of Hunan Province, School of Medicine, Hunan Normal University, Changsha, China.
Department of Sport, Physical Education and Health, Centre for Health and Exercise Science Research, Hong Kong Baptist University, Hong Kong, China.
Sci Rep. 2022 Feb 14;12(1):2410. doi: 10.1038/s41598-021-00825-2.
The present study aimed to distinguish different hypertriglyceridemic waist phenotypes and relevant risks of developing fatty liver and abnormal glycometabolic profiles in overweight/obese adults. A total of 1221 Chinese adults with mean (standard deviation [SD]) age of 37 (9) years, 37.3% males and 62.7% females, body mass index (BMI) of 29.0 (4.0) kg/m, triglyceride (TG) 2.04 (1.45) mmol/L, and waist circumference (WC) 95.8 (10.7) cm were included and classified into four phenotypes: normal TG & normal WC (N-N); normal TG & high WC (N-WC); high TG & normal WC (TG-N); high TG & high WC (TG-WC). Participants in TG-WC group had the highest BMI, WC, blood pressure (BP), insulin, Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), glycosylated hemoglobin (HbA1c), low-density lipoprotein cholesterol (LDL), and fatty liver. Participants within N-WC group had a significantly higher risk of fatty liver (adjusted OR 3.50 [95% CI 2.05-5.97]), as well as TG-N (adjusted OR 2.59 [95% CI 1.61-4.16]) and TG-WC (adjusted OR 4.12 [95% CI 2.28-7.46]). The risk of elevated HOMA-IR was significantly higher in TG-N (adjusted OR 2.16 [95% CI 1.33-3.50]) and TG-WC (adjusted OR 2.04 [95% CI 1.22-3.40]). The risk of elevated HbA1c was significantly higher in the TG-WC (adjusted OR 2.79 [95% CI 1.47-5.31]). Hypertriglyceridemic waist phenotype can be a potential and cost-effective method to identify individuals with a high risk of fatty liver and glycometabolic disorders.
本研究旨在区分不同的高三酰甘油性腰围表型，并确定超重/肥胖成年人发生脂肪肝和糖代谢异常的相关风险。共纳入 1221 名中国成年人，平均（标准差）年龄为 37（9）岁，男性占 37.3%，女性占 62.7%，体重指数（BMI）为 29.0（4.0）kg/m2，三酰甘油（TG）为 2.04（1.45）mmol/L，腰围（WC）为 95.8（10.7）cm，并将其分为 4 种表型：正常 TG 和正常 WC（N-N）；正常 TG 和高 WC（N-WC）；高 TG 和正常 WC（TG-N）；高 TG 和高 WC（TG-WC）。TG-WC 组的 BMI、WC、血压（BP）、胰岛素、稳态模型评估的胰岛素抵抗（HOMA-IR）、糖化血红蛋白（HbA1c）、低密度脂蛋白胆固醇（LDL）和脂肪肝均最高。与 N-WC 组相比，N-WC 组发生脂肪肝的风险显著升高（校正比值比 3.50[95%置信区间 2.05-5.97]），TG-N（校正比值比 2.59[95%置信区间 1.61-4.16]）和 TG-WC（校正比值比 4.12[95%置信区间 2.28-7.46]）也显著升高。TG-N（校正比值比 2.16[95%置信区间 1.33-3.50]）和 TG-WC（校正比值比 2.04[95%置信区间 1.22-3.40]）的 HOMA-IR 升高风险显著升高。TG-WC 组的 HbA1c 升高风险显著升高（校正比值比 2.79[95%置信区间 1.47-5.31]）。高三酰甘油性腰围表型可能是一种潜在的、具有成本效益的方法，可用于识别发生脂肪肝和糖代谢异常风险较高的个体。
