Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, Malaga University, Instituto de Investigación Biomédica de Malaga (IBIMA), Malaga, Spain.
Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain.
Obesity (Silver Spring). 2020 Mar;28(3):537-543. doi: 10.1002/oby.22728.
The hypertriglyceridemic waist (HTGW) phenotype is characterized by abdominal obesity and high levels of triglycerides. In a cross-sectional assessment of PREDIMED-Plus trial participants at baseline, HTGW phenotype prevalence was evaluated, associated risk factors were analyzed, and the lifestyle of individuals with metabolic syndrome and HTGW was examined.
A total of 6,874 individuals aged 55 to 75 with BMI ≥ 27 and < 40 kg/m were included and classified by presence (HTGW ) or absence (HTGW ) of HTGW (waist circumference: men ≥ 102 cm, women ≥ 88 cm; fasting plasma triglycerides ≥ 150 mg/dL). Analytical parameters and lifestyle (energy intake and expenditure) were analyzed.
A total of 38.2% of the sample met HTGW criteria. HTGW individuals tended to be younger, have a greater degree of obesity, be sedentary, and be tobacco users. They had higher peripheral glucose, total cholesterol, and low-density lipoprotein cholesterol levels; had lower high-density lipoprotein cholesterol levels; and had increased prevalence of type 2 diabetes mellitus. Mediterranean diet (MedDiet) adherence and physical activity were greater in HTGW patients. Age, BMI, tobacco use, total energy expenditure, hypertension, type 2 diabetes mellitus, and MedDiet adherence were associated with HTGW .
HTGW is a highly prevalent phenotype in this population associated with younger age, higher BMI, tobacco use, and decreased MedDiet adherence. HTGW individuals were more physically active with greater total physical activity, and fewer had hypertension.
高甘油三酯血症腰围（HTGW）表型的特征是腹部肥胖和甘油三酯水平升高。在 PREDIMED-Plus 试验参与者的基线横断面评估中，评估了 HTGW 表型的患病率，分析了相关危险因素，并检查了代谢综合征和 HTGW 个体的生活方式。
共纳入 6874 名年龄在 55 至 75 岁之间、BMI≥27 且<40kg/m2的个体，根据是否存在 HTGW（腰围：男性≥102cm，女性≥88cm；空腹血浆甘油三酯≥150mg/dL）对其进行分类。分析了分析参数和生活方式（能量摄入和支出）。
共有 38.2%的样本符合 HTGW 标准。HTGW 个体往往更年轻，肥胖程度更高，久坐不动，且是烟民。他们的外周血糖、总胆固醇和低密度脂蛋白胆固醇水平更高；高密度脂蛋白胆固醇水平较低；且 2 型糖尿病的患病率更高。地中海饮食（MedDiet）的依从性和身体活动在 HTGW 患者中更高。年龄、BMI、吸烟、总能量消耗、高血压、2 型糖尿病和 MedDiet 依从性与 HTGW 相关。
在该人群中，HTGW 是一种高度普遍的表型，与年龄较小、BMI 较高、吸烟和 MedDiet 依从性降低有关。HTGW 个体的身体活动量更大，总身体活动量更多，且高血压的发生率更低。
