小儿骶管麻醉后布比卡因的血浆游离水平：地西泮预处理的影响？
Bupivacaine free plasma levels in children after caudal anaesthesia: influence of pretreatment with diazepam?
作者信息
Bruguerolle B, Giaufre E, Morisson-Lacombe G, Rousset-Rouviere B, Arnaud C
机构信息
Laboratoire de Pharmacologie Médicale et Clinique, Faculté de Médecine de Marseille, France.
出版信息
Fundam Clin Pharmacol. 1990;4(2):159-61. doi: 10.1111/j.1472-8206.1990.tb00483.x.
Diazepam-induced modifications in bupivacaine distribution have been noted in previously reported data investigating the influence of diazepam on bupivacaine plasma levels in children undergoing surgery under caudal block with a mixture of lignocaine and bupivacaine. Possible diazepam-induced changes in protein binding were therefore examined in this study. Our data did not demonstrate significant modifications in bupivacaine protein binding when diazepam is used concomitantly.
在先前报道的数据中，已经注意到地西泮对布比卡因分布的影响，这些数据研究了地西泮对在利多卡因和布比卡因混合液骶管阻滞下接受手术的儿童布比卡因血浆水平的影响。因此，本研究检测了地西泮可能引起的蛋白质结合变化。我们的数据并未表明同时使用地西泮时布比卡因的蛋白质结合有显著改变。
Zotero 插件