Giaufre E, Bruguerolle B, Morrison-Lacombe G, Rousset-Rouviere B
Surgical Pediatric Department, Saint-Joseph Foundation Hospital, Marseille, France.
Acta Anaesthesiol Scand. 1990 Jan;34(1):44-6. doi: 10.1111/j.1399-6576.1990.tb03039.x.
Twenty children undergoing surgery received a caudal block using 1 ml per kg of a mixture of 50% lidocaine (1%) and 50% bupivacaine (0.25%). They were randomly allocated to two groups, one of which received midazolam 0.4 mg/kg rectally as premedication. Midazolam administration resulted in a significantly lower AUC value for lidocaine but did not influence the plasma concentrations of bupivacaine.
20名接受手术的儿童使用每千克1毫升的50%利多卡因（1%）和50%布比卡因（0.25%）混合液进行骶管阻滞。他们被随机分为两组，其中一组直肠给予咪达唑仑0.4毫克/千克作为术前用药。给予咪达唑仑导致利多卡因的AUC值显著降低，但不影响布比卡因的血浆浓度。
