Kosova F, Altan N, Sepici A, Engin A, Kocamanoglu N
Celal Bayar University School of Health, Manisa, Turkey.
Bratisl Lek Listy. 2013;114(4):183-8. doi: 10.4149/bll_2013_039.
Free radicals, oxidative stress, and antioxidants have become commonly used terms in modern discussion of disease mechanisms. Accumulation of evidence suggests that toxic oxygen-derived reactive free radicals (superoxide, peroxide and hydroxyl radicals) play a crucial role in etiology of diabetes and its complication. Thus, it was aimed to determine the role of thyroid hormones in reversal of antioxidatant enzyme activities and lipid peroxidation alterations observed in experimentally induced diabetic rat hearts. The present study investigates the antioxidant enzyme activities such as SOD, CAT, GSH-Px and lipid peroxidation products in cardiac tissues of streptozotosin (STZ)-induced diabetic rats before and after thyroidectomy. Our results showed that CAT, GPx enzyme activities and FOX, MDA levels were increased (p<0.05) during diabetes, hypothyroidism and hypothyroidism with diabetes, which can be regulated in different percentages with treatment of insulin and various doses of thyroid hormone ((p<0.05). In conclusion, in this study, the possible contribution of thyroid hormones to the insulin effect of normalizing the induced diabetic changes in cardiac tissue and serum of rat has been seen (Tab. 5, Ref. 32).
自由基、氧化应激和抗氧化剂已成为现代疾病机制讨论中常用的术语。越来越多的证据表明，有毒的氧衍生活性自由基（超氧化物、过氧化物和羟基自由基）在糖尿病及其并发症的病因中起着关键作用。因此，本研究旨在确定甲状腺激素在逆转实验性诱导糖尿病大鼠心脏中观察到的抗氧化酶活性和脂质过氧化改变方面的作用。本研究调查了链脲佐菌素（STZ）诱导的糖尿病大鼠甲状腺切除前后心脏组织中的抗氧化酶活性，如超氧化物歧化酶（SOD）、过氧化氢酶（CAT）、谷胱甘肽过氧化物酶（GSH-Px）以及脂质过氧化产物。我们的结果表明，在糖尿病、甲状腺功能减退以及糖尿病合并甲状腺功能减退期间，CAT、GPx酶活性以及氧化型谷胱甘肽（FOX）、丙二醛（MDA）水平均升高（p<0.05），通过胰岛素和不同剂量甲状腺激素治疗可在不同程度上对其进行调节（p<0.05）。总之，在本研究中，已观察到甲状腺激素对使大鼠心脏组织和血清中诱导的糖尿病变化恢复正常的胰岛素作用可能具有的贡献（表5，参考文献32）。
